In April 2025, we officially launched the IEK-CHANGES project with a two-day workshop, including some of the key partners and collaborators of the project. The workshop “Understanding biocultural changes in the ancestral homelands of the Tsimane’ people, Beni Department, Bolivia” provided a forum to share different perspectives and insights on the biocultural changes taking place in the Tsimane’ Territory in Bolivian Amazonia, and the different methodological approaches available to document and make sense of such changes. We will share lessons learned from previous research projects conducted with or by the Tsimane’ people, as well as other Indigenous Peoples in Bolivia, to understand the different processes through which the biocultural nexus between people and place establishes and perpetuates itself, can be disrupted and broken, or sustained and restored.